Category: Science & Geography|
The author of the book: Elizabeth Pownall
Format files: PDF, EPUB, TXT, DOCX
The size of the: 33.75 MB
Edition: Morgan & Claypool Publishers
Date of issue: 15 August 2010
Description of the book "FGF Signaling in Vertebrate Development":This review will explore examples from several vertebrate model organisms and include discussions of the role of fibroblast growth factors (FGF) signaling in regulating the establishment of the mesoderm, neural patterning, morphogenesis, myogenesis, limb development and the establishment of right-left asymmetry. The FGF represent one of the relatively few families of extracellular signaling peptides that have been shown in recent decades to be key regulators of metazoan development. FGFs are required for multiple processes in both protostome and deuterostome groups. Given the wide range of regulatory roles attributed to the FGFs, it is perhaps not surprising that mis PDF-regulation of this signaling pathway has been implicated in a number of human disease conditions. The focus of the present review is to look at the fundamental components of the FGF pathway and illustrate how this highly conserved regulatory cassette has been deployed to regulate multiple, diverse processes during vertebrate development.
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